WHR is considered a good indicator of internal fat distribution on a person. The higher your muscle mass the higher your BMR will be. Note that ECW is usually high if ICW is high.īMR is the minimum amount of energy required (calories) to sustain vital functions whilst at rest. Note that as muscles are cells, high muscle mass = high cells = high ICW.ĮCW is the water outside the cells. The sum of your Total Body Water, Protein, Minerals, and Body Fat Mass. Is your weight minus your Body Fat Mass (how much you would weight if you had no fat on your body) The sum of Your Total Body Water, Protein and Non-Osseous Minerals (calculated by deducting your Bone Mineral Content from the total Minerals). If you have more lean mass, the weight of bones strength, which in turn increases the bone mineral. Mineral mass is closely related to soft lean mass. The osseous mineral is bone, where non-osseous minerals are those found in all other parts of the body. Minerals consist of two types, osseous mineral, and non-osseous minerals. Ideally, your protein content should be within or exceed the average range set out below the reading. Therefore, a lack of protein suggests a lack of intracellular water, which in turn suggests poor nutrition. Protein is directly related to intracellular water. A lack of protein implies a lack of muscle mass is possibly indicating poor nutrition and malnourishment. Protein consists of nitrogen, and high nitrogen levels within cells indicate good levels of muscle mass and health. Usually, individuals with a higher degree of muscle mass will have higher levels of TBW. Ideally, your TBW should be in the normal range or over. The FAT score is a new, simple, semiquantitative evaluation of human scAT fibrosis that may help identify patients with a potential limited weight-loss response to RYGB.TBW is all the water in the body and is approximately 60% of your total weight. The association remained significant after adjustment for age, diabetes status, hypertension, percent fat mass, and interleukin-6 level (adjusted odds ratio, 3.6 95% confidence interval, 1.8 to 7.2 P = 0.003). FAT score ≥2 was significantly associated with PR. FAT score interobserver agreement was good (κ = 0.76). The link between FAT score and PR was tested in univariate and multivariate models.įAT score was directly associated with increasing scAT fibrosis measured by a standard quantification method (P for trend <0.001). PR to RYGB was defined as <28% of total weight loss at 1 year (lowest tertile). Using this score, we characterized 183 perioperative scAT biopsy specimens from severely obese patients who underwent RYGB (n = 85 from a training cohort n = 98 from a confirmation cohort). We created a fibrosis score of adipose tissue (FAT score) integrating perilobular and pericellular fibrosis. To create a semiquantitative score evaluating scAT fibrosis and test its predictive value on weight-loss response after Roux-en-Y gastric bypass (RYGB). Quantification of subcutaneous adipose tissue (scAT) fibrosis is negatively associated with post-BS weight loss, but whether it could constitute a predictor applicable in clinical routine remains to be demonstrated. Factors predicting poor weight-loss response (PR) need to be identified to improve patient care. 10 Sorbonne Universités, IRD, UMI 209, UMMISCO, IRD France Nord, F-93143 Bondy, France.īariatric surgery (BS) induces major and sustainable weight loss in many patients. 9 Department of Digestive and Hepato-Pancreato-Biliary Surgery, Liver Transplantation, Pitié-Salpêtrière Hospital, AP-HP, F-75013 Paris, France.8 Department of General, Digestive, and Metabolic Surgery, Ambroise Paré University Hospital, AP-HP, Versailles Saint-Quentin University, F-92100 Boulogne, France.7 Centre de Recherche Bichat-Beaujon, INSERM U773, University Paris-Diderot, F-75018 Paris, France.6 Beaujon Hospital, Pathology Department, AP-HP, F-92110 Clichy, France.5 Department of Pathology, Pitié-Salpêtrière Hospital, AP-HP, UIMAP, UPMC Université Paris 06, F-75013 Paris, France.4 Nutrition Department, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), F-75013 Paris, France.3 Sorbonne Universités, UPMC Université Paris 06, UMRS1166, F-75005 Paris France.2 INSERM, UMRS 1166, Nutriomic Team 6, F-75013 Paris, France.1 Institute of Cardiometabolism and Nutrition (ICAN) F-75013 Paris France.
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